منابع مشابه
The cardiac IKs channel, complex indeed.
T he cardiac IKs channel is a major repolarization current in the heart that responds rapidly and robustly to sympathetic nervous system stimulation to ensure adequate diastolic filling time in the face of accompanying accelerated heart rate. In cardiac myocytes, the IKs channel is a macromolecular complex composed of a poreforming α (KCNQ1) subunit and modulatory β (KCNE1) subunit, as well as ...
متن کاملStoichiometry of the cardiac IKs complex.
Nothing is easy for ion channels that assemble with membrane-embedded regulatory subunits. Something as trivial yet as fundamental as counting the number of subunits in an ion channel complex can be challenging and marred with controversy. The most infamous stoichiometric debate in the ion channel field has been over the potassium (K) channel complex that generates the repolarizing cardiac IKsl...
متن کاملThe cardiac IKs potassium channel macromolecular complex includes the phosphodiesterase PDE4D3.
The cardiac I(Ks) potassium channel is a macromolecular complex consisting of alpha-(KCNQ1) and beta-subunits (KCNE1) and the A kinase-anchoring protein (AKAP) Yotiao (AKAP-9), which recruits protein kinase A) and protein phosphatase 1 to the channel. Here, we have tested the hypothesis that specific cAMP phosphodiesterase (PDE) isoforms of the PDE4D family that are expressed in the heart are a...
متن کاملCharybdotoxin Binding in the IKs Pore Demonstrates Two MinK Subunits in Each Channel Complex
I(Ks) voltage-gated K(+) channels contain four pore-forming KCNQ1 subunits and MinK accessory subunits in a number that has been controversial. Here, I(Ks) channels assembled naturally by monomer subunits are compared to those with linked subunits that force defined stoichiometries. Two strategies that exploit charybdotoxin (CTX)-sensitive subunit variants are applied. First, CTX on rate, off r...
متن کاملPolyunsaturated fatty acid analogs act antiarrhythmically on the cardiac IKs channel.
Polyunsaturated fatty acids (PUFAs) affect cardiac excitability. Kv7.1 and the β-subunit KCNE1 form the cardiac IKs channel that is central for cardiac repolarization. In this study, we explore the prospects of PUFAs as IKs channel modulators. We report that PUFAs open Kv7.1 via an electrostatic mechanism. Both the polyunsaturated acyl tail and the negatively charged carboxyl head group are req...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2010
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1014150107